Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
نویسندگان
چکیده
Novel substituted chromenopyridones (3a-j and 6a-d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.
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عنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013